Gum mastic increases maspin expression in prostate cancer cells
نویسندگان
چکیده
منابع مشابه
Gum mastic inhibits the expression and function of the androgen receptor in prostate cancer cells.
Accumulating evidence suggests that the androgen receptor (AR) may play an important role in the development and progression of prostate cancer. To find new, useful compounds that effectively may attenuate the function of AR in prostate cancer cells, the authors investigated the effect of gum mastic, a natural resin, on AR activity. An androgen-responsive prostate cancer cell line LNCaP was use...
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Andriana Kaliora, 70 El. Venizelou Ave., 176 71 Kallithea, Athens, Greece Tel: ++3019549303-306, Fax: ++3019577050, e-mail: [email protected] Pistacia lentiscus var. Chia (Anacardiaceae) is a tree unique to the island of Chios and grows only in the Southern part of the island. A resinous exudate is produced after longitudinal incisions are made at close intervals from the base of the trunk up to ...
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Mammary Serine Protease Inhibitor (Maspin) is a unique member of the serpin family with tumor suppressive properties. Maspin is a secreted protein encoded by a class II tumor suppressor gene, expressed in normal prostate luminal and basal cells but reduced or absent in prostate cancer. Currently, there is a consensus that maspin expression in prostate cancer is an indicator of a better prognosi...
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Standard therapy for nonorgan confined prostate cancer aims to block the production or action of androgens. Although initially successful, antiandrogen therapy eventually fails and androgen depletion independent (ADI) disease emerges. Remarkably, ADI prostate cancers still rely on a functional androgen receptor (AR). Aberrant expression of coregulatory proteins required for the formation of pro...
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PURPOSE Expression of tumor suppressor gene, MASPIN, is associated with inhibition of tumor cell invasion and metastasis. Loss of or decreased expression of Maspin is found frequently in breast and prostate cancer cells. The objective of this study is to investigate Maspin expression in prostate tumor specimens and explore the mechanisms of hormonal regulation of Maspin expression in prostate t...
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ژورنال
عنوان ژورنال: Acta Pharmacologica Sinica
سال: 2007
ISSN: 1671-4083,1745-7254
DOI: 10.1111/j.1745-7254.2007.00535.x